The immediate cause of death was acute liver disease, culminating in end-stage liver failure. Charles's physical decline became public knowledge during the summer of 2003 when severe hip discomfort forced him to cancel a tour for the first time in several decades. He underwent successful hip replacement surgery in late 2003, but routine clinical examinations revealed severe underlying hepatic damage.
Charles had spent decades enduring grueling tour itineraries, performing over 200 dates a year well into his sixties and seventies. That unrelenting work ethic masked his physical exhaustion. By early 2004, fluid retention, severe weight loss, and general organ distress left him unable to travel. His longtime spokesperson, Jerry Digney, disclosed that Charles was fully aware of his prognosis during his final weeks. He focused his remaining strength on supervising audio mixes at his RPM International headquarters in Los Angeles rather than hospital confinement.